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butabarbital will lower the level or outcome of nicardipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.butabarbital will lessen the extent or result of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.butabarbital will lower the extent or impact of levoketoconazole